Description

Leucovorin Calcium Tablets – Prescription Folate Analog

Leucovorin Calcium Tablets contain leucovorin, a reduced folate and folic acid analog used in specific clinical situations. In the first place, these prescription tablets are taken orally and may be used to reduce the toxicity of methotrexate when methotrexate elimination is impaired, or to reduce toxicity following an overdose of certain folic acid antagonists or dihydrofolate reductase (DHFR) inhibitors. Current U.S. labeling also includes treatment of cerebral folate transport deficiency in patients with a confirmed FOLR1 gene variant.

Also, Leucovorin Calcium Tablets are available in 5 mg, 10 mg, 15 mg, and 25 mg strengths, depending on the manufacturer and product. The tablets are intended for oral administration and should be taken exactly as prescribed by a qualified healthcare professional.

Key Features

• Active ingredient: Leucovorin
• Form: Leucovorin calcium tablets
• Medication class: Folate analog
• Route: Oral
• Common strengths: 5 mg, 10 mg, 15 mg, and 25 mg
• Prescription status: Rx only
• Clinical use: Specific methotrexate and folic acid antagonist toxicity management
• Additional labeled use: Cerebral folate transport deficiency associated with a confirmed FOLR1 gene variant

Important Safety Information

As a matter of fact, Leucovorin Calcium Tablets should be used according to the prescribing information and instructions provided by a healthcare professional. Important drug interactions can occur. More so, Current labeling identifies interactions involving certain antiepileptic medicines, trimethoprim-sulfamethoxazole, and fluorouracil.

In like manner, Leucovorin Calcium Tablets are not indicated for treating pernicious anemia or other megaloblastic anemia caused by vitamin B12 deficiency, because treatment may improve blood findings while neurological complications continue to progress.

In addition, Patients should use the exact strength and dosing schedule prescribed for their condition. Do not change the dose or frequency without medical advice.