Description

Hydrocodone / Ibuprofen Tablets | Uses, Side Effects & Safety

Hydrocodone/ibuprofen combines two medications with different pain-relieving mechanisms. Hydrocodone is a centrally acting opioid analgesic that changes how the brain and nervous system respond to pain, while ibuprofen is an NSAID that reduces substances involved in pain and inflammation. 

Current U.S. labeling describes several tablet strengths, including 2.5 mg/200 mg, 5 mg/200 mg, 7.5 mg/200 mg, and 10 mg/200 mg of hydrocodone bitartrate/ibuprofen, depending on the specific product. 

Because hydrocodone is an opioid, this medication carries important risks including addiction, abuse, misuse, overdose, and potentially life-threatening respiratory depression. It should be used at the lowest effective dose for the shortest duration appropriate for the individual treatment goal. 

Ibuprofen contributes anti-inflammatory and analgesic activity but also carries NSAID-related risks, including serious gastrointestinal bleeding, ulceration, perforation, and cardiovascular events. 

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Important Safety Information

Hydrocodone/ibuprofen is a Schedule II controlled substance in current U.S. labeling. The medication carries a boxed warning concerning addiction, abuse and misuse; potentially fatal respiratory depression; accidental ingestion; neonatal opioid withdrawal; drug interactions; and risks associated with combining opioids with benzodiazepines or other central nervous system depressants. 

Patients should not combine this medication with alcohol or other sedating medicines unless specifically instructed by their healthcare professional. Hydrocodone can cause serious or life-threatening breathing problems, while ibuprofen can increase the risk of gastrointestinal bleeding and cardiovascular complications. 

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