Description

Acetaminophen / Tramadol Tablets | Uses, Safety & Side Effects

Acetaminophen/tramadol tablets combine two analgesic ingredients with complementary pain-relieving effects. Tramadol is a centrally acting opioid analgesic, while acetaminophen is a non-opioid analgesic and antipyretic. A commonly marketed combination strength contains 37.5 mg of tramadol hydrochloride and 325 mg of acetaminophen per tablet. 

The combination is prescribed for acute pain that is severe enough to require an opioid medication and when alternative treatments have not provided adequate relief or are not appropriate. Current U.S. labeling limits this combination to short-term use of five days or less.

Because tramadol is an opioid, the medication carries important risks, including addiction, abuse, misuse, respiratory depression, and potentially fatal overdose. Tramadol can also interact with other medicines that affect serotonin and may increase the risk of seizures. 

Acetaminophen-containing medicines also require careful use because excessive total acetaminophen exposure can cause severe liver injury. Patients should check other prescription and over-the-counter medicines to avoid unintentionally taking additional acetaminophen.

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Important Safety Information

Acetaminophen/tramadol is not appropriate for everyone. It should be taken only as prescribed. Do not combine it with other tramadol-containing products or additional acetaminophen-containing products unless specifically directed by a healthcare professional. 

Patients should also discuss alcohol, sedatives, antidepressants, seizure history, breathing problems, liver or kidney disease, pregnancy, and other medications with their healthcare professional before using this medicine. Tramadol can be habit-forming, and abrupt discontinuation after physical dependence can cause withdrawal symptoms. 

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