Description
Vortioxetine For Sale (Trintellix)
Trintellix tablets come in strengths of 5 mg, 10 mg, and 20 mg, often color-coded (e.g., pink for 5 mg, yellow for 10 mg). Vortioxetine For Sale .
What is Vortioxetine Used For?
– **Primary indication**: Treatment of major depressive disorder (MDD) in adults.
– May help with cognitive symptoms of depression, such as difficulty concentrating or processing information (supported by clinical studies showing improvement in processing speed).
– Effectiveness is similar to other antidepressants, with potential benefits in patients experiencing cognitive dysfunction.
It is taken orally once daily, with or without food.
How Does Vortioxetine Work? (Mechanism of Action)
Vortioxetine has a unique **multimodal** action on serotonin:
– Inhibits serotonin reuptake (like SSRIs).
– Acts as an agonist at 5-HT1A receptors.
– Partial agonist at 5-HT1B receptors.
– Antagonist at 5-HT3, 5-HT1D, and 5-HT7 receptors.
This combination enhances serotonergic activity in the brain and may influence other neurotransmitters (e.g., dopamine, norepinephrine). The exact contribution to its antidepressant effects is not fully understood.
Dosage and Administration
– Starting dose: Usually 10 mg once daily.
– Maintenance: 5–20 mg/day, adjusted based on response and tolerability.
– Maximum: 20 mg/day.
– Can be taken with or without food; no need to taper when starting (but gradual reduction recommended when stopping higher doses).
Common Side Effects
The most frequent side effect is **nausea** (up to 32% at higher doses), often improving over time. Other common ones (>5% and twice placebo rate):
| Side Effect | Frequency |
|———————-|—————————-|
| Nausea | Very common (20–32%) |
| Vomiting | Common |
| Constipation | Common |
| Dry mouth | Common |
| Diarrhea | Common |
| Dizziness | Common |
| Sexual dysfunction | Lower than many SSRIs/SNRIs|
| Headache | Occasional |
Vortioxetine generally has a favorable profile regarding weight gain, sedation, and sexual side effects compared to some older antidepressants.
Serious Warnings and Precautions
– **Black box warning**: Increased risk of suicidal thoughts and behaviors in young adults (under 25) during initial treatment.
– **Serotonin syndrome**: Risk when combined with other serotonergic drugs (e.g., SSRIs, SNRIs, triptans, MAOIs).
– Do not use with MAOIs or within 14–21 days of stopping them.
– May increase bleeding risk (especially with NSAIDs or anticoagulants).
– Withdrawal symptoms if stopped abruptly.
– Not recommended during pregnancy or breastfeeding (Category C; discuss risks with doctor).
Who Should Not Take Vortioxetine?
– Hypersensitivity to the drug.
– Concomitant use with MAOIs.
– Caution in patients with bipolar disorder (may trigger mania).
Always consult a healthcare provider for personalized advice. This information is based on FDA-approved labeling and reliable medical sources (e.g., Drugs.com, Mayo Clinic, Wikipedia, DrugBank) as of late 2025.
