Description
Trazodone for sale
Trazodone for sale (trazodone hydrochloride) is a widely prescribed antidepressant medication belonging to the serotonin antagonist and reuptake inhibitor (SARI) class. Primarily used to treat **major depressive disorder**, it is also commonly prescribed off-label for **insomnia** due to its sedating effects. In this comprehensive guide, we’ll cover everything you need to know about trazodone, including its mechanism of action, benefits, potential risks, and important warnings.
What Is Trazodone?
Trazodone is an oral antidepressant that works by modulating serotonin levels in the brain. Unlike selective serotonin reuptake inhibitors (SSRIs), trazodone acts as both a serotonin reuptake inhibitor and a receptor antagonist. It was first approved by the FDA in 1981 and is available as generic trazodone hydrochloride tablets in strengths of 50 mg, 100 mg, 150 mg, and 300 mg.
Common brand names include Desyrel (discontinued) and Oleptro (extended-release). It’s not a controlled substance and is often chosen for its lower risk of certain side effects compared to older antidepressants like tricyclics.
How Does Trazodone Work?
Trazodone’s mechanism of action involves:
– Inhibiting serotonin reuptake
– Blocking 5-HT2A serotonin receptors
– Antagonizing alpha-1 adrenergic and histamine H1 receptors (contributing to sedation)
This dual action helps alleviate depression symptoms while promoting sleep at lower doses. Its sedating properties make it popular for treating insomnia associated with depression or as a standalone sleep aid.
Primary Uses of Trazodone (Trazodone for sale)
– **Major Depressive Disorder (MDD)**: FDA-approved for treating depression, improving mood, appetite, energy, and reducing anxiety.
– **Off-Label Uses**:
– Insomnia and sleep disorders (low doses of 25–150 mg)
– Anxiety disorders
– Fibromyalgia pain
– PTSD or alcohol withdrawal symptoms (in combination therapy)
Studies show trazodone is effective for depression comparable to SSRIs or tricyclics, with added benefits for sleep.
Trazodone Dosage Guidelines
Dosage varies by condition and individual response:
| Condition | Starting Dose | Typical Maintenance Dose | Maximum Dose |
|—————————-|————————|—————————|————–|
| Depression (Adults) | 150 mg/day (divided) | 150–400 mg/day | 600 mg/day |
| Insomnia (Off-Label) | 25–50 mg at bedtime | 50–150 mg at bedtime | 200 mg |
| Elderly or Outpatients | Lower starting dose | Gradual increases | Monitor closely |
Always start low and titrate slowly. Take with food to improve absorption and reduce dizziness. Consult a doctor for personalized dosing.
Common Side Effects of Trazodone
Most side effects are mild and may decrease over time:
– Drowsiness or sedation (most common)
– Dry mouth
– Dizziness or lightheadedness
– Headache
– Nausea or vomiting
– Blurred vision
– Constipation
Less common but serious:
– Orthostatic hypotension (low blood pressure upon standing)
– Prolonged or painful erection (priapism – seek immediate medical help)
– Heart rhythm changes (QT prolongation)
Serious Warnings and Risks
– **Black Box Warning**: Increased risk of suicidal thoughts in children, teens, and young adults (under 25). Monitor closely for mood changes.
– **Serotonin Syndrome**: Life-threatening if combined with other serotonergic drugs (e.g., SSRIs, MAOIs, triptans). Symptoms: agitation, hallucinations, rapid heart rate.
– **Interactions**: Avoid MAO inhibitors (wait 14 days). Caution with alcohol, opioids, or other CNS depressants.
– **Pregnancy/Breastfeeding**: Use only if benefits outweigh risks; consult a healthcare provider.
– **Withdrawal**: Taper off gradually to avoid discontinuation symptoms.
Do not stop trazodone abruptly without medical advice.
Who Should Avoid Trazodone?
– Allergy to trazodone
– Recent MAOI use
– Severe heart conditions (due to QT risk)
Always discuss your medical history with a healthcare professional.
Frequently Asked Questions About Trazodone
**Is trazodone addictive?** No, it’s not habit-forming like benzodiazepines, but abrupt stopping can cause withdrawal.
**How long does trazodone take to work?** For depression: 2–4 weeks. For sleep: Often within days.
**Can trazodone be used long-term?** Yes, under medical supervision.
**Is trazodone a sleeping pill?** It’s an antidepressant with strong sedating effects, often used off-label for sleep.
This information is for educational purposes only and not a substitute for professional medical advice. Sources include FDA labels, Mayo Clinic, Drugs.com, WebMD, and NCBI. Last updated: December 2025. Consult your doctor or pharmacist for personalized guidance. Trazodone for sale
