Description

Duloxetine For Sale (Cymbalta)

What is Duloxetine Used For?

Duloxetine treats several conditions, including: (Duloxetine for sale)

– **Major Depressive Disorder (MDD)** — Improves mood, sleep, appetite, and energy levels.
– **Generalized Anxiety Disorder (GAD)** — Reduces excessive worry and tension.
– **Diabetic Peripheral Neuropathic Pain** — Relieves nerve pain from diabetes.
– **Fibromyalgia** — Manages widespread musculoskeletal pain, fatigue, and sleep issues.
– **Chronic Musculoskeletal Pain** — Addresses ongoing back pain or osteoarthritis.

Off-label uses may include chemotherapy-induced neuropathy and stress urinary incontinence.

How Does Duloxetine Work?

Duloxetine inhibits the reuptake of **serotonin** and **norepinephrine**, increasing their levels in the brain. This helps regulate mood, reduce anxiety, and modulate pain signals. It may also indirectly boost dopamine in certain brain areas.

Dosage and Administration

Duloxetine comes in delayed-release capsules (20 mg, 30 mg, 40 mg, 60 mg). Swallow whole—do not crush, chew, or sprinkle unless advised (e.g., Drizalma Sprinkle).

Typical starting doses:

– Depression/Anxiety: 40-60 mg/day (often starting at 30 mg).
– Pain conditions: 60 mg once daily (may start lower).

Maximum: Usually 120 mg/day, but 60 mg is common. Adjustments needed for kidney/liver issues. Taper gradually when stopping to avoid withdrawal.

Common Side Effects

Side effects often improve over time:

– Nausea
– Dry mouth
– Drowsiness or fatigue
– Constipation
– Loss of appetite
– Increased sweating
– Sexual dysfunction (e.g., decreased libido)

Serious Side Effects and Warnings

**Black Box Warning**: Increased risk of suicidal thoughts/behaviors in children, teens, and young adults, especially early in treatment.

Other serious risks:

– **Serotonin Syndrome** → Life-threatening (symptoms: agitation, hallucinations, rapid heart rate).
– Liver damage (avoid in heavy alcohol use or liver disease).
– High blood pressure.
– Bleeding risks (especially with NSAIDs/aspirin).
– Withdrawal symptoms if stopped abruptly.

Seek immediate help for severe reactions.

Drug Interactions and Contraindications

**Contraindicated** with:

– MAO inhibitors (wait 14 days after stopping MAOI; 5 days after duloxetine).
– Uncontrolled narrow-angle glaucoma.

Major interactions:

– Other serotonergic drugs (e.g., SSRIs, triptans, tramadol) → Risk of serotonin syndrome.
– CYP1A2/CYP2D6 inhibitors (e.g., certain antibiotics, antidepressants).
– Blood thinners/NSAIDs → Increased bleeding.

Avoid alcohol, as it worsens side effects.

Precautions

– Monitor mood changes closely.
– Use caution in bipolar disorder (may trigger mania).
– Not recommended during pregnancy/breastfeeding unless benefits outweigh risks.
– May impair driving/machinery.

**Important**: This is general information, not medical advice. Always consult your healthcare provider for personalized guidance. Report side effects to FDA at 1-800-FDA-1088.