Description
Bupropion For Sale
Commonly marketed under brand names like **Wellbutrin** (for depression) and **Zyban** (for smoking cessation), it is widely used for mental health and behavioral conditions. Bupropion for sale
What is Bupropion Used For?
Bupropion is FDA-approved for:
– **Major Depressive Disorder (MDD)**: Helps alleviate symptoms of depression.
– **Seasonal Affective Disorder (SAD)**: Prevents depressive episodes during fall/winter (typically with Wellbutrin XL).
– **Smoking Cessation**: Aids in quitting smoking by reducing cravings and withdrawal symptoms (typically as Zyban or generic sustained-release).
Off-label uses include:
– Attention Deficit Hyperactivity Disorder (ADHD).
– Bipolar depression (as an adjunct).
– Weight management (in combination with naltrexone as Contrave).
– Antidepressant-induced sexual dysfunction.
It is also combined with dextromethorphan in Auvelity for rapid-acting treatment of MDD.
How Does Bupropion Work?
Bupropion is a **norepinephrine-dopamine reuptake inhibitor (NDRI)**. It blocks the reabsorption of dopamine and norepinephrine in the brain, increasing their availability. This helps improve mood, energy, concentration, and motivation. Unlike SSRIs, it has minimal effect on serotonin, which contributes to its different side effect profile (e.g., less sexual dysfunction or weight gain).
Dosage and Administration
Bupropion comes in several formulations:
– **Immediate-release (IR)**: Taken 3–4 times daily.
– **Sustained-release (SR)**: Taken twice daily (common for smoking cessation).
– **Extended-release (XL)**: Taken once daily (common for depression/SAD).
Typical starting doses:
– Depression: 150 mg/day (SR/XL), increased to 300 mg/day.
– Smoking cessation: 150 mg/day for 3 days, then 300 mg/day (SR).
– Maximum: Usually 450 mg/day (depending on formulation).
Always swallow tablets whole—do not crush or chew extended-release forms. Start treatment 1–2 weeks before target quit date for smoking cessation.
Common Side Effects
– Dry mouth
– Nausea or constipation
– Insomnia or anxiety
– Headache or dizziness
– Excessive sweating
– Tremor
These often improve over time.
Serious Side Effects and Warnings
– **Seizures**: Major risk (dose-dependent; ~0.4% at 300–450 mg). Higher risk with history of seizures, eating disorders (e.g., bulimia), head trauma, or abrupt alcohol/sedative withdrawal.
– **Increased blood pressure**: Monitor regularly, especially with nicotine patches.
– **Mental health changes**: Agitation, hostility, suicidal thoughts (especially in young adults). Black box warning for antidepressants.
– **Mania/Hypomania**: In patients with bipolar disorder.
– **Allergic reactions**: Rash, hives, swelling (rare but serious).
*Examples of bupropion tablets (e.g., Zyban 150 mg and generic forms). Appearance varies by manufacturer.*
Precautions and Contraindications
Do not use if you have:
– Seizure disorder.
– Current/past eating disorder (anorexia/bulimia).
– Abruptly stopped alcohol or sedatives.
– Are taking MAO inhibitors (wait 14 days).
Avoid alcohol, as it increases seizure risk. Not recommended during pregnancy/breastfeeding unless benefits outweigh risks.
Drug Interactions
– MAOIs: Risk of severe reactions.
– CYP2D6 substrates (e.g., certain antidepressants, beta-blockers): May increase levels.
– Drugs that lower seizure threshold (e.g., antipsychotics, steroids).
Always inform your doctor of all medications.
Bupropion remains a first-line option for many due to its energizing effects and favorable profile for sexual function and weight. Consult a healthcare provider for personalized advice, as this is not medical advice. Sources include Mayo Clinic, WebMD, Drugs.com, MedlinePlus, and FDA prescribing information (updated through 2025).
